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Document type:
journal article 
Author(s):
Jiang, Sheng-Nan; Park, Seung-Hwan; Lee, Hee Jung; Zheng, Jin Hai; Kim, Hyung-Seok; Bom, Hee-Seung; Hong, Yeongjin; Szardenings, Michael; Shin, Myung Geun; Kim, Sun-Chang; Ntziachristos, Vasilis; Choy, Hyon E; Min, Jung-Joon 
Title:
Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent. 
Abstract:
A number of recent reports have demonstrated that attenuated Salmonella typhimurium are capable of targeting both primary and metastatic tumors. The use of bacteria as a vehicle for the delivery of anticancer drugs requires a mechanism that precisely regulates and visualizes gene expression to ensure the appropriate timing and location of drug production. To integrate these functions into bacteria, we used a repressor-regulated tetracycline efflux system, in which the expression of a therapeutic...    »
 
Journal title abbreviation:
Mol Ther 
Year:
2013 
Journal volume:
21 
Journal issue:
11 
Pages contribution:
1985-95 
Language:
eng 
Print-ISSN:
1525-0016 
TUM Institution:
Lehrstuhl für Biologische Bildgebung