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Document type:
journal article 
Author(s):
Walsh, Kyle M; Codd, Veryan; Smirnov, Ivan V; Rice, Terri; Decker, Paul A; Hansen, Helen M; Kollmeyer, Thomas; Kosel, Matthew L; Molinaro, Annette M; McCoy, Lucie S; Bracci, Paige M; Cabriga, Belinda S; Pekmezci, Melike; Zheng, Shichun; Wiemels, Joseph L; Pico, Alexander R; Tihan, Tarik; Berger, Mitchell S; Chang, Susan M; Prados, Michael D; Lachance, Daniel H; O'Neill, Brian Patrick; Sicotte, Hugues; Eckel-Passow, Jeanette E; ENGAGE Consortium Telomere Group; van der Harst, Pim; Wiencke, John K...    »
 
Title:
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 
Abstract:
Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between L...    »
 
Journal title abbreviation:
Nat Genet 
Year:
2014 
Journal volume:
46 
Journal issue:
Pages contribution:
731-5 
Language:
eng 
Print-ISSN:
1061-4036 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen