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Dokumenttyp:
journal article 
Autor(en):
Mu, Xueru; Español-Suñer, Regina; Mederacke, Ingmar; Affò, Silvia; Manco, Rita; Sempoux, Christine; Lemaigre, Frédéric P; Adili, Arlind; Yuan, Detian; Weber, Achim; Unger, Kristian; Heikenwälder, Mathias; Leclercq, Isabelle A; Schwabe, Robert F 
Titel:
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment. 
Abstract:
In many organs, including the intestine and skin, cancers originate from cells of the stem or progenitor compartment. Despite its nomenclature, the cellular origin of hepatocellular carcinoma (HCC) remains elusive. In contrast to most organs, the liver lacks a defined stem cell population for organ maintenance. Previous studies suggest that both hepatocytes and facultative progenitor cells within the biliary compartment are capable of generating HCC. As HCCs with a progenitor signature carry a w...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2015 
Band / Volume:
125 
Heft / Issue:
10 
Seitenangaben Beitrag:
3891-903 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Virologie