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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Hoh, Alexander; Heeg, Maximilian; Ni, Yi; Schuch, Anita; Binder, Benedikt; Hennecke, Nadine; Blum, Hubert E; Nassal, Michael; Protzer, Ulrike; Hofmann, Maike; Urban, Stephan; Thimme, Robert
- Titel:
- Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.
- Abstract:
- CD8(+) T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8(+) T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2(hNTCP) cells that endogenously processed viral antigens and presented them to HBV-specific CD8(+) T cells. This induced cytolytic and noncytolytic CD8(+) T-cell effector functions... »
- Zeitschriftentitel:
- J Virol
- Jahr:
- 2015
- Band / Volume:
- 89
- Heft / Issue:
- 14
- Seitenangaben Beitrag:
- 7433-8
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1128/JVI.00605-15
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/25972537
- Print-ISSN:
- 0022-538X
- TUM Einrichtung:
- Institut für Virologie
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