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Dokumenttyp:
journal article 
Autor(en):
Hoh, Alexander; Heeg, Maximilian; Ni, Yi; Schuch, Anita; Binder, Benedikt; Hennecke, Nadine; Blum, Hubert E; Nassal, Michael; Protzer, Ulrike; Hofmann, Maike; Urban, Stephan; Thimme, Robert 
Titel:
Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro. 
Abstract:
CD8(+) T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8(+) T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2(hNTCP) cells that endogenously processed viral antigens and presented them to HBV-specific CD8(+) T cells. This induced cytolytic and noncytolytic CD8(+) T-cell effector functions...    »
 
Zeitschriftentitel:
J Virol 
Jahr:
2015 
Band / Volume:
89 
Heft / Issue:
14 
Seitenangaben Beitrag:
7433-8 
Sprache:
eng 
Print-ISSN:
0022-538X 
TUM Einrichtung:
Institut für Virologie