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Dokumenttyp:
journal article 
Autor(en):
Balmayor, Elizabeth R; Geiger, Johannes P; Aneja, Manish K; Berezhanskyy, Taras; Utzinger, Maximilian; Mykhaylyk, Olga; Rudolph, Carsten; Plank, Christian 
Titel:
Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats. 
Abstract:
Limitations associated to the use of growth factors represent a major hurdle to musculoskeletal regeneration. On the one hand, they are needed to induce neo-tissue formation for the substitution of a necrotic or missing tissue. On the other hand, these factors are used in supraphysiological concentrations, are short lived and expensive and result in many side effects. Here we develop a gene transfer strategy based on the use of chemically modified mRNA (cmRNA) coding for human bone morphogenetic...    »
 
Zeitschriftentitel:
Biomaterials 
Jahr:
2016 
Band / Volume:
87 
Seitenangaben Beitrag:
131-46 
Sprache:
eng 
Print-ISSN:
0142-9612 
TUM Einrichtung:
Klinik für Unfallchirurgie; Institut für experimentelle Onkologie und Therapieforschung