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Dokumenttyp:
journal article 
Autor(en):
Leucht, Stefan; Winter-van Rossum, Inge; Heres, Stephan; Arango, Celso; Fleischhacker, W Wolfgang; Glenthøj, Birte; Leboyer, Marion; Leweke, F Markus; Lewis, Shôn; McGuire, Phillip; Meyer-Lindenberg, Andreas; Rujescu, Dan; Kapur, Shitij; Kahn, René S; Sommer, Iris E 
Titel:
The optimization of treatment and management of schizophrenia in Europe (OPTiMiSE) trial: rationale for its methodology and a review of the effectiveness of switching antipsychotics. 
Abstract:
Most of the 13 542 trials contained in the Cochrane Schizophrenia Group's register just tested the general efficacy of pharmacological or psychosocial interventions. Studies on the subsequent treatment steps, which are essential to guide clinicians, are largely missing. This knowledge gap leaves important questions unanswered. For example, when a first antipsychotic failed, is switching to another drug effective? And when should we use clozapine? The aim of this article is to review the efficacy...    »
 
Zeitschriftentitel:
Schizophr Bull 
Jahr:
2015 
Band / Volume:
41 
Heft / Issue:
Seitenangaben Beitrag:
549-58 
Sprache:
eng 
Print-ISSN:
0586-7614 
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie