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Document type:
journal article 
Author(s):
Domes, Katrin; Patrucco, Enrico; Loga, Florian; Dietrich, Alexander; Birnbaumer, Lutz; Wegener, Jörg W; Hofmann, Franz 
Title:
Murine cardiac growth, TRPC channels, and cGMP kinase I. 
Abstract:
Signaling via cGMP-dependent protein kinase I (cGKI) and canonical transient receptor potential (TRPC) channels appears to be involved in the regulation of cardiac hypertrophy. Recent evidence suggests that TRPC channels are targets for cGKI, and phosphorylation of these channels may mediate the antihypertrophic effects of cGMP signaling. We tested this concept by investigating the role of cGMP/cGKI signaling on angiotensin II (A II)-induced cardiac hypertrophy using a control group (Ctr), trpc6...    »
 
Journal title abbreviation:
Pflugers Arch 
Year:
2015 
Journal volume:
467 
Journal issue:
10 
Pages contribution:
2229-34 
Language:
eng 
Print-ISSN:
0031-6768 
TUM Institution:
Institut für Pharmakologie und Toxikologie