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Dokumenttyp:
journal article 
Autor(en):
Herhaus, Peter; Habringer, Stefan; Philipp-Abbrederis, Kathrin; Vag, Tibor; Gerngross, Carlos; Schottelius, Margret; Slotta-Huspenina, Julia; Steiger, Katja; Altmann, Torben; Weisser, Tanja; Steidle, Sabine; Schick, Markus; Jacobs, Laura; Slawska, Jolanta; Mueller-Thomas, Catharina; Verbeek, Mareike; Subklewe, Marion; Peschel, Christian; Wester, Hans-Juergen; Schwaiger, Markus; Goetze, Katharina; Keller, Ulrich 
Titel:
Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia. 
Abstract:
Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. CXCR4/CXCL12 interaction is crucially involved in recruitment and retention of leukemia-initiating cells within this niche. Various drugs targeting this pathway have entered clinical trials. To evaluate CXCR4 imaging in acute myeloid leukemia, we first tested CXCR4 expression in patient-derived primary blasts. Flow cytometry revealed that high blast counts in patients with acute myel...    »
 
Zeitschriftentitel:
Haematologica 
Jahr:
2016 
Band / Volume:
101 
Heft / Issue:
Seitenangaben Beitrag:
932-40 
Sprache:
eng 
Print-ISSN:
0390-6078 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie