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Dokumenttyp:
journal article 
Autor(en):
Mall, Sabine; Yusufi, Nahid; Wagner, Ricarda; Klar, Richard; Bianchi, Henrique; Steiger, Katja; Straub, Melanie; Audehm, Stefan; Laitinen, Iina; Aichler, Michaela; Peschel, Christian; Ziegler, Sibylle; Mustafa, Mona; Schwaiger, Markus; D'Alessandria, Calogero; Krackhardt, Angela M 
Titel:
Immuno-PET Imaging of Engineered Human T Cells in Tumors. 
Abstract:
Sensitive in vivo imaging technologies applicable to the clinical setting are still lacking for adoptive T-cell-based immunotherapies, an important gap to fill if mechanisms of tumor rejection or escape are to be understood. Here, we propose a highly sensitive imaging technology to track human TCR-transgenic T cells in vivo by directly targeting the murinized constant TCR beta domain (TCRmu) with a zirconium-89 ((89)Zr)-labeled anti-TCRmu-F(ab')2 fragment. Binding of the labeled or unlabeled F(a...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2016 
Band / Volume:
76 
Heft / Issue:
14 
Seitenangaben Beitrag:
4113-23 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie