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Dokumenttyp:
journal article 
Autor(en):
Budczies, Jan; Bockmayr, Michael; Denkert, Carsten; Klauschen, Frederick; Gröschel, Stefan; Darb-Esfahani, Silvia; Pfarr, Nicole; Leichsenring, Jonas; Onozato, Maristela L; Lennerz, Jochen K; Dietel, Manfred; Fröhling, Stefan; Schirmacher, Peter; Iafrate, A John; Weichert, Wilko; Stenzinger, Albrecht 
Titel:
Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival. 
Abstract:
Inhibition of the PD-L1 (CD274) - PD-1 axis has emerged as a powerful cancer therapy that prevents evasion of tumor cells from the immune system. While immunohistochemical detection of PD-L1 was introduced as a predictive biomarker with variable power, much less is known about copy number alterations (CNA) affecting PD-L1 and their associations with expression levels, mutational load, and survival. To gain insight, we employed The Cancer Genome Atlas (TCGA) datasets to comprehensively analyze 22...    »
 
Zeitschriftentitel:
Genes Chromosomes Cancer 
Jahr:
2016 
Band / Volume:
55 
Heft / Issue:
Seitenangaben Beitrag:
626-39 
Sprache:
eng 
Print-ISSN:
1045-2257 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie