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Document type:
journal article 
Author(s):
Pfarr, Nicole; Penzel, Roland; Klauschen, Frederick; Heim, Daniel; Brandt, Regine; Kazdal, Daniel; Jesinghaus, Moritz; Herpel, Esther; Schirmacher, Peter; Warth, Arne; Weichert, Wilko; Endris, Volker; Stenzinger, Albrecht 
Title:
Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. 
Abstract:
Targeted deep massive parallel sequencing has been implemented in routine molecular diagnostics for high-throughput genetic profiling of formalin-fixed paraffin-embedded (FFPE) cancer samples. This approach is widely used to interrogate simple somatic mutations but experience with the analysis of copy number variations (CNV) is limited. Here, we retrospectively analyzed CNV in 822 cancer cases (135 melanoma, 468 non-small cell lung cancers (NSCLC), 219 colorectal cancers (CRC)). We observed a de...    »
 
Journal title abbreviation:
Genes Chromosomes Cancer 
Year:
2016 
Journal volume:
55 
Journal issue:
11 
Pages contribution:
821-33 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1045-2257 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie