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Dokumenttyp:
journal article 
Autor(en):
Pfarr, Nicole; Penzel, Roland; Klauschen, Frederick; Heim, Daniel; Brandt, Regine; Kazdal, Daniel; Jesinghaus, Moritz; Herpel, Esther; Schirmacher, Peter; Warth, Arne; Weichert, Wilko; Endris, Volker; Stenzinger, Albrecht 
Titel:
Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. 
Abstract:
Targeted deep massive parallel sequencing has been implemented in routine molecular diagnostics for high-throughput genetic profiling of formalin-fixed paraffin-embedded (FFPE) cancer samples. This approach is widely used to interrogate simple somatic mutations but experience with the analysis of copy number variations (CNV) is limited. Here, we retrospectively analyzed CNV in 822 cancer cases (135 melanoma, 468 non-small cell lung cancers (NSCLC), 219 colorectal cancers (CRC)). We observed a de...    »
 
Zeitschriftentitel:
Genes Chromosomes Cancer 
Jahr:
2016 
Band / Volume:
55 
Heft / Issue:
11 
Seitenangaben Beitrag:
821-33 
Sprache:
eng 
Print-ISSN:
1045-2257 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie