Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Scholz, Beate; Korn, Claudia; Wojtarowicz, Jessica; Mogler, Carolin; Augustin, Iris; Boutros, Michael; Niehrs, Christof; Augustin, Hellmut G 
Titel:
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling. 
Abstract:
The WNT signaling enhancer R-spondin3 (RSPO3) is prominently expressed in the vasculature. Correspondingly, embryonic lethality of Rspo3-deficient mice is caused by vessel remodeling defects. Yet the mechanisms underlying vascular RSPO3 function remain elusive. Inducible endothelial Rspo3 deletion (Rspo3-iECKO) resulted in perturbed developmental and tumor vascular remodeling. Endothelial cell apoptosis and vascular pruning led to reduced microvessel density in Rspo3-iECKO mice. Rspo3-iECKO mice...    »
 
Zeitschriftentitel:
Dev Cell 
Jahr:
2016 
Band / Volume:
36 
Heft / Issue:
Seitenangaben Beitrag:
79-93 
Sprache:
eng 
Print-ISSN:
1534-5807 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie