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Dokumenttyp:
journal article 
Autor(en):
Balluff, Benjamin; Frese, Christian K; Maier, Stefan K; Schöne, Cédrik; Kuster, Bernhard; Schmitt, Manfred; Aubele, Michaela; Höfler, Heinz; Deelder, André M; Heck, Albert J R; Hogendoorn, Pancras C W; Morreau, Johannes; Altelaar, A F Maarten; Walch, Axel; McDonnell, Liam A 
Titel:
De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. 
Abstract:
An essential and so far unresolved factor influencing the evolution of cancer and the clinical management of patients is intratumour clonal and phenotypic heterogeneity. However, the de novo identification of tumour subpopulations is so far both a challenging and an unresolved task. Here we present the first systematic approach for the de novo discovery of clinically detrimental molecular tumour subpopulations. In this proof-of-principle study, spatially resolved, tumour-specific mass spectra we...    »
 
Zeitschriftentitel:
J Pathol 
Jahr:
2015 
Band / Volume:
235 
Heft / Issue:
Seitenangaben Beitrag:
3-13 
Sprache:
eng 
Print-ISSN:
0022-3417 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie