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Dokumenttyp:
journal article 
Autor(en):
Dzien, Piotr; Kettunen, Mikko I; Marco-Rius, Irene; Serrao, Eva M; Rodrigues, Tiago B; Larkin, Timothy J; Timm, Kerstin N; Brindle, Kevin M 
Titel:
(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo. 
Abstract:
Aldehyde dehydrogenase (ALDH2) is an emerging drug target for the treatment of heart disease, cocaine and alcohol dependence, and conditions caused by genetic polymorphisms in ALDH2. Noninvasive measurement of ALDH2 activity in vivo could inform the development of these drugs and accelerate their translation to the clinic.[1-(13) C, U-(2) H5 ] ethanol was hyperpolarized using dynamic nuclear polarization, injected into mice and its oxidation in the liver monitored using (13) C MR spectroscopy an...    »
 
Zeitschriftentitel:
Magn Reson Med 
Jahr:
2015 
Band / Volume:
73 
Heft / Issue:
Seitenangaben Beitrag:
1733-40 
Sprache:
eng 
Print-ISSN:
0740-3194 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik