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Dokumenttyp:
journal article 
Autor(en):
Mendler, Claudia T; Gehring, Torben; Wester, Hans-Jürgen; Schwaiger, Markus; Skerra, Arne 
Titel:
??Zr-Labeled Versus ¹²?I-Labeled ?HER2 Fab with Optimized Plasma Half-Life for High-Contrast Tumor Imaging In Vivo. 
Abstract:
Immuno-PET imaging of the tumor antigen HER2/neu allows for the noninvasive detection and monitoring of oncogene expression; such detection and monitoring are of prognostic value in patients with breast cancer. Compared with the full-size antibody trastuzumab, smaller protein tracers with more rapid blood clearance permit higher imaging contrast at earlier time points. Antigen-binding fragments (Fabs) of antibodies with moderately prolonged circulation achieved through the genetic fusion with a...    »
 
Zeitschriftentitel:
J Nucl Med 
Jahr:
2015 
Band / Volume:
56 
Heft / Issue:
Seitenangaben Beitrag:
1112-8 
Sprache:
eng 
Print-ISSN:
0161-5505 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik