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Document type:
journal article 
Author(s):
Safaiyan, Shima; Kannaiyan, Nirmal; Snaidero, Nicolas; Brioschi, Simone; Biber, Knut; Yona, Simon; Edinger, Aimee L; Jung, Steffen; Rossner, Moritz J; Simons, Mikael 
Title:
Age-related myelin degradation burdens the clearance function of microglia during aging. 
Abstract:
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunc...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2016 
Journal volume:
19 
Journal issue:
Pages contribution:
995-8 
Language:
eng 
Print-ISSN:
1097-6256 
TUM Institution:
Institut für Neurowissenschaften