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Document type:
journal article 
Author(s):
Busche, Marc Aurel; Konnerth, Arthur 
Title:
Impairments of neural circuit function in Alzheimer's disease. 
Abstract:
An essential feature of Alzheimer's disease (AD) is the accumulation of amyloid-? (A?) peptides in the brain, many years to decades before the onset of overt cognitive symptoms. We suggest that during this very extended early phase of the disease, soluble A? oligomers and amyloid plaques alter the function of local neuronal circuits and large-scale networks by disrupting the balance of synaptic excitation and inhibition (E/I balance) in the brain. The analysis of mouse models of AD revealed that...    »
 
Journal title abbreviation:
Philos Trans R Soc Lond B Biol Sci 
Year:
2016 
Journal volume:
371 
Journal issue:
1700 
Language:
eng 
Print-ISSN:
0962-8436 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Neurowissenschaften