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Document type:
journal article 
Author(s):
Lehnert, Sandra; Hartmann, Stephanie; Hessler, Sabine; Adelsberger, Helmuth; Huth, Tobias; Alzheimer, Christian 
Title:
Ion channel regulation by ?-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease. 
Abstract:
?-site APP-cleaving enzyme 1 (BACE1) has become infamous for its pivotal role in the pathogenesis of Alzheimer's disease (AD). Consequently, BACE1 represents a prime target in drug development. Despite its detrimental involvement in AD, it should be quite obvious that BACE1 is not primarily present in the brain to drive mental decline. In fact, additional functions have been identified. In this review, we focus on the regulation of ion channels, specifically voltage-gated sodium and KCNQ potassi...    »
 
Journal title abbreviation:
Channels (Austin) 
Year:
2016 
Journal volume:
10 
Journal issue:
Pages contribution:
365-378 
Language:
eng 
Print-ISSN:
1933-6950 
TUM Institution:
Institut für Neurowissenschaften