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Document type:
journal article 
Author(s):
Lehmann-Horn, Klaus; Sagan, Sharon A; Bernard, Claude C A; Sobel, Raymond A; Zamvil, Scott S 
Title:
B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity. 
Abstract:
Natalizumab, which binds very late antigen-4 (VLA-4), is a potent therapy for multiple sclerosis (MS). Studies have focused primarily upon its capacity to interfere with T-cell migration into the central nervous system (CNS). B cells are important in MS pathogenesis and express high levels of VLA-4. Here, we report that the selective inhibition of VLA-4 expression on B cells impedes CNS accumulation of B cells, and recruitment of Th17 cells and macrophages, and reduces susceptibility to experime...    »
 
Journal title abbreviation:
Ann Neurol 
Year:
2015 
Journal volume:
77 
Journal issue:
Pages contribution:
902-8 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0364-5134 
TUM Institution:
Neurologische Klinik und Poliklinik