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- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Nischwitz, S; Wolf, C; Andlauer, T F M; Czamara, D; Zettl, U K; Rieckmann, P; Buck, D; Ising, M; Bettecken, T; Mueller-Myhsok, B; Weber, F
- Title:
- MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene.
- Abstract:
- Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associa... »
- Journal title abbreviation:
- J Neuroimmunol
- Year:
- 2015
- Journal volume:
- 279
- Pages contribution:
- 46-9
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.jneuroim.2015.01.008
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/25670000
- Print-ISSN:
- 0165-5728
- TUM Institution:
- Neurologische Klinik und Poliklinik
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