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Dokumenttyp:
journal article 
Autor(en):
Milde, Ronny; Ritter, Julia; Tennent, Glenys A; Loesch, Andrzej; Martinez, Fernando O; Gordon, Siamon; Pepys, Mark B; Verschoor, Admar; Helming, Laura 
Titel:
Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction. 
Abstract:
Multinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute to the removal of debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large and complement-opsonized materials more effectively than their unfused M2 macrophage precursors. MGC expression of complement receptor 4 (CR4) was increased, but it functioned primarily as an adhesion integrin. In contrast, although expression of CR3 was not increased, it became f...    »
 
Zeitschriftentitel:
Cell Rep 
Jahr:
2015 
Band / Volume:
13 
Heft / Issue:
Seitenangaben Beitrag:
1937-48 
Sprache:
eng 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene