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Document type:
journal article 
Author(s):
Erny, Daniel; Hrab? de Angelis, Anna Lena; Jaitin, Diego; Wieghofer, Peter; Staszewski, Ori; David, Eyal; Keren-Shaul, Hadas; Mahlakoiv, Tanel; Jakobshagen, Kristin; Buch, Thorsten; Schwierzeck, Vera; Utermöhlen, Olaf; Chun, Eunyoung; Garrett, Wendy S; McCoy, Kathy D; Diefenbach, Andreas; Staeheli, Peter; Stecher, Bärbel; Amit, Ido; Prinz, Marco 
Title:
Host microbiota constantly control maturation and function of microglia in the CNS. 
Abstract:
As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. We observed substantial contributions of the host microbiota to microglia homeostasis, as germ-free (GF) mice displayed global defects in microglia with altered cell proportions and an immature phenotype, leading to impaired innate immune responses. Temporal eradication of host microbiota severely c...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2015 
Journal volume:
18 
Journal issue:
Pages contribution:
965-77 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1097-6256 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene