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Dokumenttyp:
journal article 
Autor(en):
van Blijswijk, Janneke; Schraml, Barbara U; Rogers, Neil C; Whitney, Paul G; Zelenay, Santiago; Acton, Sophie E; Reis E Sousa, Caetano 
Titel:
Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells. 
Abstract:
Dendritic cells (DCs) are key regulators of innate and adaptive immunity. Our understanding of immune function has benefited greatly from mouse models allowing for selective ablation of DCs. Many such models rely on transgenic diphtheria toxin receptor (DTR) expression driven by DC-restricted promoters. This renders DCs sensitive to DT but is otherwise thought to have no effect on immune physiology. In this study, we report that, unexpectedly, mice in which DTR is expressed on conventional DCs d...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2015 
Band / Volume:
194 
Heft / Issue:
Seitenangaben Beitrag:
307-15 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene