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Document type:
journal article 
Author(s):
Fiebiger, Benjamin M; Pfister, Heike; Behrends, Uta; Mautner, Josef 
Title:
Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing. 
Abstract:
Peptides presented on major histocompatibility complex (MHC) class I molecules are generated via cytosolic proteolysis. However, the nature of the endogenous peptide precursors and the intracellular processing steps preceding protein degradation remain poorly defined. Here, we assessed whether ubiquitination is an essential signal for proteasomal cleavage of antigen substrates in human cells. Conversion into antigenic peptides occurred in the absence of any detectable N-terminal ubiquitination o...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2015 
Journal volume:
45 
Journal issue:
Pages contribution:
716-27 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0014-2980 
TUM Institution:
Kinderklinik und Poliklinik