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Document type:
journal article 
Author(s):
Yu, Xiaojun; Ilecka, Marta; Bartlett, Emmalene J; Schneidt, Viktor; Bhat, Rauf; Mautner, Josef; Feederle, Regina; Delecluse, Henri-Jacques 
Title:
Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells. 
Abstract:
The treatment of non-Hodgkin lymphomas has benefited enormously from the introduction of monoclonal antibody-based therapies. However, the efficacy of these treatments varies with lymphoma subtypes and typically decreases with subsequent relapses. Here, we report on antigen-armed antibodies (AgAbs) as a potential treatment of B-cell lymphoma. AgAbs include antigens from ubiquitous pathogens, such as Epstein-Barr virus (EBV), that persist in their host and elicit strong lifelong T-cell responses....    »
 
Journal title abbreviation:
Blood 
Year:
2015 
Journal volume:
125 
Journal issue:
10 
Pages contribution:
1601-10 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Kinderklinik und Poliklinik