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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rieber, Nikolaus; Singh, Anurag; Öz, Hasan; Carevic, Melanie; Bouzani, Maria; Amich, Jorge; Ost, Michael; Ye, Zhiyong; Ballbach, Marlene; Schäfer, Iris; Mezger, Markus; Klimosch, Sascha N; Weber, Alexander N R; Handgretinger, Rupert; Krappmann, Sven; Liese, Johannes; Engeholm, Maik; Schüle, Rebecca; Salih, Helmut Rainer; Marodi, Laszlo; Speckmann, Carsten; Grimbacher, Bodo; Ruland, Jürgen; Brown, Gordon D; Beilhack, Andreas; Loeffler, Juergen; Hartl, Dominik
Title:
Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.
Abstract:
Despite continuous contact with fungi, immunocompetent individuals rarely develop pro-inflammatory antifungal immune responses. The underlying tolerogenic mechanisms are incompletely understood. Using both mouse models and human patients, we show that infection with the human pathogenic fungi Aspergillus fumigatus and Candida albicans induces a distinct subset of neutrophilic myeloid-derived suppressor cells (MDSCs), which functionally suppress T and NK cell responses. Mechanistically, pathogeni...     »
Journal title abbreviation:
Cell Host Microbe
Year:
2015
Journal volume:
17
Journal issue:
4
Pages contribution:
507-14
Language:
eng
Fulltext / DOI:
doi:10.1016/j.chom.2015.02.007
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25771792
Print-ISSN:
1931-3128
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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