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Document type:
journal article 
Author(s):
Rieber, Nikolaus; Singh, Anurag; Öz, Hasan; Carevic, Melanie; Bouzani, Maria; Amich, Jorge; Ost, Michael; Ye, Zhiyong; Ballbach, Marlene; Schäfer, Iris; Mezger, Markus; Klimosch, Sascha N; Weber, Alexander N R; Handgretinger, Rupert; Krappmann, Sven; Liese, Johannes; Engeholm, Maik; Schüle, Rebecca; Salih, Helmut Rainer; Marodi, Laszlo; Speckmann, Carsten; Grimbacher, Bodo; Ruland, Jürgen; Brown, Gordon D; Beilhack, Andreas; Loeffler, Juergen; Hartl, Dominik 
Title:
Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells. 
Abstract:
Despite continuous contact with fungi, immunocompetent individuals rarely develop pro-inflammatory antifungal immune responses. The underlying tolerogenic mechanisms are incompletely understood. Using both mouse models and human patients, we show that infection with the human pathogenic fungi Aspergillus fumigatus and Candida albicans induces a distinct subset of neutrophilic myeloid-derived suppressor cells (MDSCs), which functionally suppress T and NK cell responses. Mechanistically, pathogeni...    »
 
Journal title abbreviation:
Cell Host Microbe 
Year:
2015 
Journal volume:
17 
Journal issue:
Pages contribution:
507-14 
Language:
eng 
Print-ISSN:
1931-3128 
TUM Institution:
Kinderklinik und Poliklinik; Institut für Klinische Chemie und Pathobiochemie