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Document type:
journal article 
Author(s):
Schuettler, Dominik; Piontek, Guido; Wirth, Markus; Haller, Bernhard; Reiter, Rudolf; Brockhoff, Gero; Pickhard, Anja 
Title:
Selective inhibition of EGFR downstream signaling reverses the irradiation-enhanced migration of HNSCC cells. 
Abstract:
Irradiation, which is one of the standard therapies used to treat squamous cell carcinoma of the head and neck (HNSCC), has been linked to enhanced tumor migration in carcinomas. In this study, we demonstrated that irradiation induced the phosphorylation of AKT, p38 MAPK and ERK. The combined activation of these pathways caused inactivation of GSK3? kinase, resulting in enhanced tumor cell migration. Here, we describe that the exclusive and specific inhibition of just one of the aforementioned k...    »
 
Journal title abbreviation:
Am J Cancer Res 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
2660-72 
Language:
eng 
TUM Institution:
Hals-, Nasen-, Ohrenklinik und Poliklinik; Institut für Medizinische Statistik und Epidemiologie