User: Guest  Login
Document type:
journal article 
Author(s):
Jilg, S; Reidel, V; Müller-Thomas, C; König, J; Schauwecker, J; Höckendorf, U; Huberle, C; Gorka, O; Schmidt, B; Burgkart, R; Ruland, J; Kolb, H-J; Peschel, C; Oostendorp, R A J; Götze, K S; Jost, P J 
Title:
Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients. 
Abstract:
Deregulated apoptosis is an identifying feature of myelodysplastic syndromes (MDS). Whereas apoptosis is increased in the bone marrow (BM) of low-risk MDS patients, progression to high-risk MDS correlates with an acquired resistance to apoptosis and an aberrant expression of BCL-2 proteins. To overcome the acquired apoptotic resistance in high-risk MDS, we investigated the induction of apoptosis by inhibition of pro-survival BCL-2 proteins using the BCL-2/-XL/-W inhibitor ABT-737 or the BCL-2-se...    »
 
Journal title abbreviation:
Leukemia 
Year:
2016 
Journal volume:
30 
Journal issue:
Pages contribution:
112-23 
Language:
eng 
Print-ISSN:
0887-6924 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Orthopädische und Sportorthopädische Klinik und Poliklinik; Institut für Klinische Chemie und Pathobiochemie