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Dokumenttyp:
journal article 
Autor(en):
Hu, Desheng; Mohanta, Sarajo K; Yin, Changjun; Peng, Li; Ma, Zhe; Srikakulapu, Prasad; Grassia, Gianluca; MacRitchie, Neil; Dever, Gary; Gordon, Peter; Burton, Francis L; Ialenti, Armando; Sabir, Suleman R; McInnes, Iain B; Brewer, James M; Garside, Paul; Weber, Christian; Lehmann, Thomas; Teupser, Daniel; Habenicht, Livia; Beer, Michael; Grabner, Rolf; Maffia, Pasquale; Weih, Falk; Habenicht, Andreas J R 
Titel:
Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin ? Receptors. 
Abstract:
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe(-/-) mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4(+) T cells, generated CD4(+), CD8(+), T regulatory (Treg) effector and central memory cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual set of d...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2015 
Band / Volume:
42 
Heft / Issue:
Seitenangaben Beitrag:
1100-15 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik