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Dokumenttyp:
journal article 
Autor(en):
Grinberg-Bleyer, Yenkel; Dainichi, Teruki; Oh, Hyunju; Heise, Nicole; Klein, Ulf; Schmid, Roland M; Hayden, Matthew S; Ghosh, Sankar 
Titel:
Cutting edge: NF-?B p65 and c-Rel control epidermal development and immune homeostasis in the skin. 
Abstract:
Psoriasis is an inflammatory skin disease in which activated immune cells and the proinflammatory cytokine TNF are well-known mediators of pathogenesis. The transcription factor NF-?B is a key regulator of TNF production and TNF-induced proinflammatory gene expression, and both the psoriatic transcriptome and genetic susceptibility further implicate NF-?B in psoriasis etiopathology. However, the role of NF-?B in psoriasis remains controversial. We analyzed the function of canonical NF-?B in the...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2015 
Band / Volume:
194 
Heft / Issue:
Seitenangaben Beitrag:
2472-6 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik