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Dokumenttyp:
journal article 
Autor(en):
Rad, Roland; Rad, Lena; Wang, Wei; Strong, Alexander; Ponstingl, Hannes; Bronner, Iraad F; Mayho, Matthew; Steiger, Katja; Weber, Julia; Hieber, Maren; Veltkamp, Christian; Eser, Stefan; Geumann, Ulf; Öllinger, Rupert; Zukowska, Magdalena; Barenboim, Maxim; Maresch, Roman; Cadiñanos, Juan; Friedrich, Mathias; Varela, Ignacio; Constantino-Casas, Fernando; Sarver, Aaron; Ten Hoeve, Jelle; Prosser, Haydn; Seidler, Barbara; Bauer, Judith; Heikenwälder, Mathias; Metzakopian, Emmanouil; Krug, Anne; Eh...    »
 
Titel:
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. 
Abstract:
Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic insertional mutagenesis screen. We identify Foxp1 as an oncogenic transcription factor that drives pancreatic cancer invasion and spread in a mouse model and correlates with lymph node metastasis in human patients with pancreatic cancer. The propensity of piggyBac for open chromatin also enabled genome-wide screening for cancer-relevant noncoding DN...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2015 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
47-56 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie; Institut für Virologie