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Dokumenttyp:
journal article 
Autor(en):
Kiermayer, Claudia; Northrup, Emily; Schrewe, Anja; Walch, Axel; de Angelis, Martin Hrabe; Schoensiegel, Frank; Zischka, Hans; Prehn, Cornelia; Adamski, Jerzy; Bekeredjian, Raffi; Ivandic, Boris; Kupatt, Christian; Brielmeier, Markus 
Titel:
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium. 
Abstract:
Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart-specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. The significance of Txnrd2 in aging cardiomyocytes, however, has not yet been examined.The tamoxifen-inducible heart-specific ?MHC-MerCreMer transgene was used to inactivate loxP-flanked Txnrd2 alleles in adult mice. Hearts and isolated mitochondria from a...    »
 
Zeitschriftentitel:
J Am Heart Assoc 
Jahr:
2015 
Band / Volume:
Heft / Issue:
Sprache:
eng 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik