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Document type:
journal article 
Author(s):
Bongiovanni, Dario; Ziegler, Tilman; D'Almeida, Sascha; Zhang, Tianqiong; Ng, Judy K M; Dietzel, Steffen; Hinkel, Rabea; Kupatt, Christian 
Title:
Thymosin ?4 attenuates microcirculatory and hemodynamic destabilization in sepsis. 
Abstract:
The actin polymerization regulator Thymosin ?4 (T?4) has been shown to be involved in angiogenesis, wound healing, cell survival and anti-inflammatory responses. We have previously shown that T?4 is capable of recruiting pericytes, thus stabilizing the endothelial barrier function. Here, we analyzed whether treatment with T?4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.Fourteen days before L...    »
 
Journal title abbreviation:
Expert Opin Biol Ther 
Year:
2015 
Journal volume:
15 Suppl 1 
Pages contribution:
S203-10 
Language:
eng 
Print-ISSN:
1471-2598 
TUM Institution:
I. Medizinische Klinik und Poliklinik