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Dokumenttyp:
journal article 
Autor(en):
Schneider, Simon; Koch, Werner; Hoppmann, Petra; Ubrich, Romy; Kemmner, Stephan; Steinlechner, Eva; Heemann, Uwe; Laugwitz, Karl-Ludwig; Kastrati, Adnan; Baumann, Marcus 
Titel:
Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease. 
Abstract:
Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence that Toll-like receptor 4 (TLR4) modulate inflammation and contribute to age-dependent SBP increase. However, there are no data about TLR4 and age-dependent blood pressure increase in human.We therefor investigate a human cohort of 2679 patients with CAD aged between 50-80 years. Genotypes were determined for the TLR4 single nucleotide polymorphism rs4986790 (TLR4 896A/G). Patients were stratified according to tertiles of age and the upper tertile was compared to lower tertiles. In this cohort we show that older patients with the TLR4 896 G allele had significantly lower SBP (TLR4 G allele carriers: 148.2 ± 30.4 mmHg versus A/A allele carrier: 154.9 ± 27.2 mmHg; P< 0.05) and lower pulse pressure (TLR4 G allele carriers: 69.1 ± 29.7 mmHg versus A/A allele carrier: 75.5 ± 26.4 mmHg; P< 0.05) as compared to TLR4 896A/A allele carrier.We demonstrate an association between the TLR4 SNP rs4986790 genotype and age-dependant blood pressure increase in patients with coronary artery disease. 
Zeitschriftentitel:
Immun Ageing 
Jahr:
2015 
Band / Volume:
12 
Seitenangaben Beitrag:
Sprache:
eng 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; Klinik für Herz- und Kreislauferkrankungen; Abteilung für Nephrologie