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Dokumenttyp:
journal article 
Autor(en):
Diener, Susanne; Schorpp, Kenji; Strom, Tim-Matthias; Hadian, Kamyar; Lorenz-Depiereux, Bettina 
Titel:
Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling. 
Abstract:
Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine key regulator of phosphate homeostasis. It inhibits renal tubular phosphate reabsorption by activating receptor complexes composed of FGF receptor 1c (FGFR1c) and the co-receptor Klotho. As a major signaling pathway mitogen-activated protein kinase (MAPK) pathway is employed. In this study, we established an FGF23-inducible cell model by stably expressing human Klotho in HEK293 cells (HEK293-KL cells) containing endogenous FGF recep...    »
 
Zeitschriftentitel:
Assay Drug Dev Technol 
Jahr:
2015 
Band / Volume:
13 
Heft / Issue:
Seitenangaben Beitrag:
476-87 
Sprache:
eng 
Print-ISSN:
1540-658X 
TUM Einrichtung:
Institut für Humangenetik