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Dokumenttyp:
journal article 
Autor(en):
Pers, Tune H; Karjalainen, Juha M; Chan, Yingleong; Westra, Harm-Jan; Wood, Andrew R; Yang, Jian; Lui, Julian C; Vedantam, Sailaja; Gustafsson, Stefan; Esko, Tonu; Frayling, Tim; Speliotes, Elizabeth K; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Boehnke, Michael; Raychaudhuri, Soumya; Fehrmann, Rudolf S N; Hirschhorn, Joel N; Franke, Lude; Wood, Andrew R; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan; Chu, Audrey Y; Estrada, Karol; Luan, Jian...    »
 
Titel:
Biological interpretation of genome-wide association studies using predicted gene functions. 
Abstract:
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2015 
Band / Volume:
Seitenangaben Beitrag:
5890 
Sprache:
eng 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen; Institut für Humangenetik