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Dokumenttyp:
journal article 
Autor(en):
Moutsianas, Loukas; Jostins, Luke; Beecham, Ashley H; Dilthey, Alexander T; Xifara, Dionysia K; Ban, Maria; Shah, Tejas S; Patsopoulos, Nikolaos A; Alfredsson, Lars; Anderson, Carl A; Attfield, Katherine E; Baranzini, Sergio E; Barrett, Jeffrey; Binder, Thomas M C; Booth, David; Buck, Dorothea; Celius, Elisabeth G; Cotsapas, Chris; D'Alfonso, Sandra; Dendrou, Calliope A; Donnelly, Peter; Dubois, Bénédicte; Fontaine, Bertrand; Lar Fugger, Lars; Goris, An; Gourraud, Pierre-Antoine; Graetz, Christi...    »
 
Titel:
Class II HLA interactions modulate genetic risk for multiple sclerosis. 
Abstract:
Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2015 
Band / Volume:
47 
Heft / Issue:
10 
Seitenangaben Beitrag:
1107-13 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
Neurologische Klinik und Poliklinik; Lehrstuhl für Neurogenetik