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Dokumenttyp:
journal article 
Autor(en):
Li, Jin, J; Jørgensen, Silje F, SF; Maggadottir, S Melkorka, SM; Bakay, Marina, M; Warnatz, Klaus, K; Glessner, Joseph, J; Pandey, Rahul, R; Salzer, Ulrich, U; Schmidt, Reinhold E, RE; Perez, Elena, E; Resnick, Elena, E; Goldacker, Sigune, S; Buchta, Mary, M; Witte, Torsten, T; Padyukov, Leonid, L; Videm, Vibeke, V; Folseraas, Trine, T; Atschekzei, Faranaz, F; Elder, James T, JT; Nair, Rajan P, RP; Winkelmann, Juliane, J; Gieger, Christian, C; Nöthen, Markus M, MM; Büning, Carsten, C; Brand, Ste...    »
 
Titel:
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. 
Abstract:
Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overlap with autoimmune disorders. Here, in the largest genetic study performed in CVID to date, we compare 778 CVID cases with 10,999 controls across 123,127 single-nucleotide polymorphi...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2015 
Band / Volume:
Seitenangaben Beitrag:
6804 
Sprache:
eng 
TUM Einrichtung:
r Humangenetik