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Document type:
journal article 
Author(s):
International Multiple Sclerosis Genetics Consortium. Electronic address: cotsapas@broadinstitute.org; International Multiple Sclerosis Genetics Consortium; Antel, Jack; Ban, Maria; Baranzini, Sergio; Barcellos, Lisa; Barizzone, Nadia; Beecham, Ashley; Berge, Tone; Bernardinelli, Luisa; Booth, David; Bos, Steffan; Buck, Dorothea; Butkiewicz, Mariusz; Celius, Elisabeth G; Comabella, Manuel; Compston, Alastair; Dedham, Katrina; Cotsapas, Chris; D' Alfonso, Sandra; De Jager, Phil; Dubois, Benedicte...    »
 
Title:
NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk. 
Abstract:
A recent study by Wang et al. (2016a) claims that the low-frequency variant NR1H3 p.Arg415Gln is sufficient to cause multiple sclerosis in certain individuals and determines a patient's likelihood of primary progressive disease. We sought to replicate this finding in the International MS Genetics Consortium (IMSGC) patient collection, which is 13-fold larger than the collection of Wang et al. (2016a), but we find no evidence that this variant is associated with either MS or disease subtype. Wang...    »
 
Journal title abbreviation:
Neuron 
Year:
2016 
Journal volume:
92 
Journal issue:
Pages contribution:
333-335 
Language:
eng 
Print-ISSN:
0896-6273 
TUM Institution:
Neurologische Klinik und Poliklinik