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Document type:
journal article 
Author(s):
Lehmann-Horn, Klaus; Wang, Sheng-Zhi; Sagan, Sharon A; Zamvil, Scott S; von Büdingen, H-Christian 
Title:
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue. 
Abstract:
Ectopic lymphoid tissues (ELT) can be found in multiple sclerosis (MS) and other organ-specific inflammatory conditions. Whether ELT in the meninges of central nervous system (CNS) autoimmune disease exhibit local germinal center (GC) activity remains unknown. In an experimental autoimmune encephalomyelitis model of CNS autoimmunity, we found activation-induced cytidine deaminase, a GC-defining enzyme, in meningeal ELT (mELT) densely populated by B and T cells. To determine GC activity in mELT,...    »
 
Journal title abbreviation:
JCI Insight 
Year:
2016 
Journal volume:
Journal issue:
20 
Pages contribution:
e87234 
Language:
eng 
Print-ISSN:
TUM Institution:
Neurologische Klinik und Poliklinik