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Dokumenttyp:
journal article 
Autor(en):
Einspieler, Ingo; Thürmel, Klaus; Pyka, Thomas; Eiber, Matthias; Wolfram, Sabine; Moog, Philipp; Reeps, Christian; Essler, Markus 
Titel:
Imaging large vessel vasculitis with fully integrated PET/MRI: a pilot study. 
Abstract:
The aim of this study was to evaluate the feasibility of hybrid [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/MRI in patients with large vessel vasculitis (LVV) by comparing visual and quantitative parameters to that of PET/CT. Furthermore, the value of PET/MRI in disease activity and extent of LVV was assessed.A total of 16 [(18)F]FDG PET/MRI and 12 [(18)F]-FDG PET/CT examinations were performed in 12 patients with LVV. MRI of the vessel wall by T1-weighted and T2-weighted sequences was used for anatomical localization of FDG uptake and identification of morphological changes associated with LVV. In addition, contrast-enhanced (CE) magnetic resonance angiography (MRA) was performed. The vascular FDG uptake in the vasculitis group was compared to a reference group of 16 patients using a four-point visual score. Visual scores and quantitative parameters [maximum standardized uptake value (SUVmax) and target to background ratio (TBR)] were compared between PET/MRI and PET/CT. Furthermore, correlations between C-reactive protein (CRP) and quantitative PET results, as well the extent of vasculitis in PET, MRI/CE-MRA and combined PET/MRI, were analysed.TBRs, SUVmax values and visual scores correlated well between PET/MRI and PET/CT (r = 0.92, r = 0.91; r = 0.84, p< 0.05). There was no significant difference between both modalities concerning SUVmax measurements and visual scores. In PET/MRI, PET alone revealed abnormal FDG uptake in 86 vascular regions. MRI/CE-MRA indicated 49 vessel segments with morphological changes related to vasculitis, leading to a total number of 95 vasculitis regions in combination with PET. Strong and significant correlations between CRP and disease extent in PET alone (r = 0.75, p = 0.0067) and PET/MRI (r = 0.92, p< 0.0001) in contrast to MRI/CE-MRA only were observed. Regarding disease activity, no significant correlations were seen between quantitative PET results and CRP, although there was a trend towards significance (r = 0.55, p = 0.0651). PET/MRI also showed active LVV in 15/16 examinations.Hybrid PET/MRI is feasible in LVV and holds promise for precisely determining disease extent and disease activity. 
Zeitschriftentitel:
Eur J Nucl Med Mol Imaging 
Jahr:
2015 
Band / Volume:
42 
Heft / Issue:
Seitenangaben Beitrag:
1012-24 
Sprache:
eng 
Print-ISSN:
1619-7070 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik; Abteilung für Nephrologie; Klinik für Gefäßchirurgie