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Document type:
journal article 
Author(s):
Moe, Sharon M; Chertow, Glenn M; Parfrey, Patrick S; Kubo, Yumi; Block, Geoffrey A; Correa-Rotter, Ricardo; Drüeke, Tilman B; Herzog, Charles A; London, Gerard M; Mahaffey, Kenneth W; Wheeler, David C; Stolina, Maria; Dehmel, Bastian; Goodman, William G; Floege, Jürgen; Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators*; Santos, J; Najun Zarazaga, C; Marin, I; Garrote, N; Cusumano, A; Peñalba, N; Del Valle, E; Juncos, L; Martinez Saye, J; Lef, L; Al...    »
 
Title:
Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial. 
Abstract:
Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events.This was a secondary analysis of a randomized clinical trial...    »
 
Journal title abbreviation:
Circulation 
Year:
2015 
Journal volume:
132 
Journal issue:
Pages contribution:
27-39 
Language:
eng 
Print-ISSN:
0009-7322 
TUM Institution:
Abteilung für Nephrologie