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Document type:
journal article 
Author(s):
de Zeeuw, Dick; Bekker, Pirow; Henkel, Elena; Hasslacher, Christopher; Gouni-Berthold, Ioanna; Mehling, Heidrun; Potarca, Antonia; Tesar, Vladimir; Heerspink, Hiddo J Lambers; Schall, Thomas J; CCX140-B Diabetic Nephropathy Study Group; Goodkin, David; Muirhead, Norman; Wang, Chao; Jadoul, M; Maes, B; Van Gaal, L; Engelen, W; Le Moine, A; Bammens, B; Tesar, V; Kubina, D; Paulyskova, P; Vezda, P; Dvorak, K; Chmelickova, H; Macel, I; Parmova, E; Saudek, F; Psottova, J; Olsovsky, J; Lecian, D; Vese...    »
 
Title:
The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial. 
Abstract:
Patients with type 2 diabetes and nephropathy have high cardiorenal morbidity and mortality despite optimum treatment including angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). Residual risk is related to residual albuminuria. We assessed whether CCX140-B, a selective inhibitor of C-C chemokine receptor type 2 (CCR2), could further reduce albuminuria when given in addition to standard care, including ACE inhibitors or ARBs.In this randomised, double-blind,...    »
 
Journal title abbreviation:
Lancet Diabetes Endocrinol 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
687-96 
Language:
eng 
Print-ISSN:
2213-8587 
TUM Institution:
Abteilung für Nephrologie