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Dokumenttyp:
journal article 
Autor(en):
Chaudhari, Sweena M; Sluimer, Judith C; Koch, Miriam; Theelen, Thomas L; Manthey, Helga D; Busch, Martin; Caballero-Franco, Celia; Vogel, Frederick; Cochain, Clément; Pelisek, Jaroslav; Daemen, Mat J; Lutz, Manfred B; Görlach, Agnes; Kissler, Stephan; Hermanns, Heike M; Zernecke, Alma 
Titel:
Deficiency of HIF1? in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. 
Abstract:
Although immune responses drive the pathogenesis of atherosclerosis, mechanisms that control antigen-presenting cell (APC)-mediated immune activation in atherosclerosis remain elusive. We here investigated the function of hypoxia-inducible factor (HIF)-1? in APCs in atherosclerosis.We found upregulated HIF1? expression in CD11c(+) APCs within atherosclerotic plaques of low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice. Conditional deletion of Hif1a in CD11c(+) APCs in high-fat diet-fed...    »
 
Zeitschriftentitel:
Arterioscler Thromb Vasc Biol 
Jahr:
2015 
Band / Volume:
35 
Heft / Issue:
11 
Seitenangaben Beitrag:
2316-25 
Sprache:
eng 
Print-ISSN:
1079-5642 
TUM Einrichtung:
Klinik für Gefäßchirurgie; Klinik für Kinderkardiologie und angeborene Herzfehler