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Dokumenttyp:
journal article 
Autor(en):
Demel, Hans-Richard; Feuerecker, Benedikt; Piontek, Guido; Seidl, Christof; Blechert, Birgit; Pickhard, Anja; Essler, Markus 
Titel:
Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells. 
Abstract:
Hallmarks of cancer cells comprise altered glucose metabolism (aerobic glycolysis) and differences in DNA damage response (DDR). Glucose transporters (GLUT), glycolytic enzymes such as hexokinase (HK) and metabolic pathways (e.g. PI3K/Akt/mTor) have been shown to be upregulated in multiple myeloma and other cancer cell lines. Here we have investigated the effects of clinically used inhibitors of topoisomerases, of DDR and of the PI3K/Akt/mTor pathway on glucose metabolism and on cell survival in...    »
 
Zeitschriftentitel:
Am J Cancer Res 
Jahr:
2015 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1649-64 
Sprache:
eng 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik; Frauenklinik und Poliklinik; Hals-, Nasen-, Ohrenklinik und Poliklinik