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Dokumenttyp:
journal article 
Autor(en):
Painter, Jodie N; O'Mara, Tracy A; Batra, Jyotsna; Cheng, Timothy; Lose, Felicity A; Dennis, Joe; Michailidou, Kyriaki; Tyrer, Jonathan P; Ahmed, Shahana; Ferguson, Kaltin; Healey, Catherine S; Kaufmann, Susanne; Hillman, Kristine M; Walpole, Carina; Moya, Leire; Pollock, Pamela; Jones, Angela; Howarth, Kimberley; Martin, Lynn; Gorman, Maggie; Hodgson, Shirley; National Study of Endometrial Cancer Genetics Group (NSECG); CHIBCHA Consortium; De Polanco, Ma Magdalena Echeverry; Sans, Monica; Carra...    »
 
Titel:
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. 
Abstract:
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genoty...    »
 
Zeitschriftentitel:
Hum Mol Genet 
Jahr:
2015 
Band / Volume:
24 
Heft / Issue:
Seitenangaben Beitrag:
1478-92 
Sprache:
eng 
Print-ISSN:
0964-6906 
TUM Einrichtung:
Frauenklinik und Poliklinik