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Dokumenttyp:
journal article 
Autor(en):
Seubert, Bastian; Cui, Haissi; Simonavicius, Nicole; Honert, Katja; Schäfer, Sandra; Reuning, Ute; Heikenwalder, Mathias; Mari, Bernard; Krüger, Achim 
Titel:
Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization. 
Abstract:
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways but, so far, it is unclear, how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-like phenotype concomitant with increased E-cadherin expression, downregulation of its repressors Slug and Zeb1, and decreased N-cadherin. In addition, ?-catenin protein was markedly reduced, negatively...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2015 
Band / Volume:
136 
Heft / Issue:
10 
Seitenangaben Beitrag:
2304-15 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
Institut für Virologie; Institut für experimentelle Onkologie und Therapieforschung; Frauenklinik und Poliklinik