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Dokumenttyp:
journal article 
Autor(en):
Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S; Beaudry, Jacqueline L; Puviindran, Vijitha; Abdennur, Nezar A; Liu, Jannel; Svensson, Per-Arne; Hsu, Yi-Hsiang; Drucker, Daniel J; Mellgren, Gunnar; Hui, Chi-Chung; Hauner, Hans; Kellis, Manolis 
Titel:
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. 
Abstract:
Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this association remains elusive.We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with the aim of dissecting the regulatory circuitry and mechanistic basis of the association between the FTO r...    »
 
Zeitschriftentitel:
N Engl J Med 
Jahr:
2015 
Band / Volume:
373 
Heft / Issue:
10 
Seitenangaben Beitrag:
895-907 
Sprache:
eng 
Print-ISSN:
0028-4793 
TUM Einrichtung:
Klinik für Ernährungsmedizin