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Document type:
journal article 
Author(s):
Wollny, Damian; Zhao, Sheng; Everlien, Isabelle; Lun, Xiaokang; Brunken, Jan; Brüne, Daniel; Ziebell, Frederik; Tabansky, Inna; Weichert, Wilko; Marciniak-Czochra, Anna; Martin-Villalba, Ana 
Title:
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas. 
Abstract:
Acinar cells make up the majority of all cells in the pancreas, yet the source of new acinar cells during homeostasis remains unknown. Using multicolor lineage-tracing and organoid-formation assays, we identified the presence of a progenitor-like acinar cell subpopulation. These cells have long-term self-renewal capacity, albeit in a unipotent fashion. We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells. Transcriptome analysis of single acinar cells reve...    »
 
Journal title abbreviation:
Dev Cell 
Year:
2016 
Journal volume:
39 
Journal issue:
Pages contribution:
289-301 
Language:
eng 
Print-ISSN:
1534-5807 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie